· All these common nightshade weeds can be handled in much the same way when gettingrid of them. As with any type of weed removal, try natural control options first and then move on to chemical control methods as a last resort. · Discover how to remove deadly nightshade from your yard with our expert guide, including tips on how to organically eliminate this vigorous and lethal plant · To permanently remove a nightshade vine from your landscape, select one of three eradication methods. Grab nightshade at the bottom of the vine where it emerges from the ground and pull, being careful not to break the roots in the process, advises King County, Washington. To remove nightshade in garden beds, pull seedlings, dig roots, mulch deeply, and spot-treat regrowth with triclopyr or glyphosate where allowed. Nightshade shows up fast, climbs over shrubs, and drops glossy berries that birds spread. Pull as much as you can. Try to get as much of the roots as possible. If you have to rely on only pulling it & cannot spray herbicides, it will take several attempts. You don't have to be afraid that nightshade is in your garden. Just keep pulling it out & don't eat it. · Learn how to identify and safely remove deadly nightshade. Discover the plant's distinctive features and the best techniques for removal without risking your health. Put on your gloves and gather the digging tools. It's a good idea to avoid contact with the plant. Loosen the soil around the plant with a pitchfork or shovel. Go as wide as possible because you want to remove the entire root system. Pull the plant out by the root.